Many transgender people take hormones as part of a gender transition. Trans people must think about their reproductive options before they start hormones. Hormones can change their bodies so they can’t ever make children.
In the case of hormones, talk to your healthcare provider about your goals. You can start and stop hormones if you want to try them for a while. Some people try them for a few weeks or a few months to see how they feel. You can stop and restart anytime, but it’s a good idea to do it under a doctor’s care.
Below is a suggested hormone regimen for transgender women (aka male to female, MTF) and transfeminine people.
Anti-androgen or testosterone blocker
- Spironolactone 100 – 200 mg/day (up to 400 mg)
- Cyproterone acetate 50–100 mg/day
Under the skin option:
- GnRH agonists 3.75 mg subcutaneous monthly
Estrogen (estradiol and others)
- Oral conjugated estrogens 2.5–7.5mg/day
- Oral 17-beta estradiol 2–6mg/day
Injected option: (aka parenterally, i.m., intramuscular, or subcutaneous)
- Estradiol valerate 5–20mg i.m./2 weeks or cypionate 2–10mg i.m./week
- Estradiol patch 0.1–0.4mg/2X week
Monitoring for transgender women (MTF) on hormone therapy:
- Monitor for feminizing and adverse effects every 3 months for first year and then every 6– 12 months.
- Monitor serum testosterone and estradiol at follow-up visits with a practical target in the female range (testosterone 30 – 100 ng/dl; E2 <200 pg/ml).
- Monitor prolactin and triglycerides before start- ing hormones and at follow-up visits.
- Monitor potassium levels if the patient is taking spironolactone.
- BMD screening before starting hormones for patients at risk for osteoporosis. Otherwise, start screening at age 60 or earlier if sex hormone levels are consistently low.
- MTF patients should be screened for breast and prostate cancer appropriately.
Source: Progress on the road to better medical care for transgender patients.