Sebastiaan E. E. Schagen and transgender people

Sebastiaan E. E. Schagen is a Dutch clinical researcher who has been involved in research and care for trans and gender diverse youth.

Background

Schagen earned a medical degree from the University of Amsterdam, then went on to specialize in pediatric endocrinology, with a particular focus on transgender healthcare. Schagen has contributed significantly to the understanding of medical treatments for gender-diverse adolescents, particularly regarding puberty suppression and gender-affirming hormone therapies.

Schagen has evaluated the safety and efficacy of gonadotropin-releasing hormone analogs (GnRH analogs) and gender-affirming hormones in adolescents. Schagen’s research focuses on the physiological and psychological effects of these treatments, contributing to the development of evidence-based guidelines for transgender healthcare.

Schagen has also written on ethics and decision-making processes in transgender healthcare, particularly concerning minors.

Selected publications by Schagen

Schagen, S. E. E., Wouters, F. M., Cohen-Kettenis, P. T., Gooren, L. J., & Hannema, S. E. (2020). Bone Development in Transgender Adolescents Treated With GnRH Analogues and Subsequent Gender-Affirming Hormones. The Journal of Clinical Endocrinology & Metabolism, 105(12), e4252–e4263. https://doi.org/10.1210/clinem/dgaa604

Brik, T., Vrouenraets, L. J. J. J., Schagen, S. E. E., Meissner, A., de Vries, M. C., & Hannema, S. E. (2019). Use of Fertility Preservation Among a Cohort of Transgirls in the Netherlands. Journal of Adolescent Health, 64(5), 589–593. https://doi.org/10.1016/j.jadohealth.2018.11.008

During Puberty Suppression and Gender-Affirming Hormone Treatment in Adolescents With Gender Dysphoria. The Journal of Sexual Medicine, 15(9), 1357–1363. https://doi.org/10.1016/j.jsxm.2018.07.017

Hannema SE, Schagen SEE, Cohen-Kettenis PT, Delemarre-van de Waal HA. (2017). Efficacy and safety of pubertal induction using 17β-estradiol in transgirls. The Journal of Clinical Endocrinology & Metabolism, 102(7), 2356–2363. https://doi.org/10.1210/jc.2016-3684

Schagen, S. E. E., Cohen-Kettenis, P. T., Delemarre-van de Waal, H. A., & Hannema, S. E. (2016). Efficacy and Safety of Gonadotropin-Releasing Hormone Agonist Treatment to Suppress Puberty in Gender Dysphoric Adolescents. The Journal of Sexual Medicine, 13(7), 1125–1132. https://doi.org/10.1016/j.jsxm.2016.05.004

Staphorsius AS, Kreukels BPC, Cohen-Kettenis PT, Veltman DJ, Burke SM, Schagen SEE, Wouters FM, Delemarre-van de Waal HA, Bakker J. (2015). Puberty suppression and executive functioning: an fMRI-study in adolescents with gender dysphoria. Psychoneuroendocrinology, 56, 190–199. https://doi.org/10.1016/j.psyneuen.2015.03.007

Hoekzema, E., Schagen, S. E. E., Kreukels, B. P. C., Veltman, D. J., Cohen-Kettenis, P. T., Delemarre-van de Waal, H., & Bakker, J. (2015). Regional volumes and spatial volumetric distribution of gray matter in the gender dysphoric brain. Psychoneuroendocrinology, 55, 59–71. https://doi.org/10.1016/j.psyneuen.2015.01.016

Soleman, R. S., Schagen, S. E. E., Veltman, D. J., Kreukels, B. P. C., Cohen-Kettenis, P. T., Lambalk, C. B., Wouters, F., & Delemarre-van de Waal, H. A. (2013). Sex Differences in Verbal Fluency During Adolescence: A Functional Magnetic Resonance Imaging Study in Gender Dysphoric and Control Boys and Girls. The Journal of Sexual Medicine, 10(8), 1969–1977. https://doi.org/10.1111/jsm.12083

Bui, H. N., Schagen, S. E. E., Klink, D. T., Delemarre-van de Waal, H. A., Blankenstein, M. A., & Heijboer, A. C. (2013). Salivary testosterone in female-to-male transgender adolescents during treatment with intra-muscular injectable testosterone esters. Steroids, 78(1), 91–95. https://doi.org/10.1016/j.steroids.2012.10.006

Schagen SEE, Delemarre-van de Waal HA, Blanchard R, Cohen-Kettenis PT. (2012). Sibling sex ratio and birth order in early-onset gender dysphoric adolescents. Archives of Sexual Behavior 41, 541–549. https://doi.org/10.1007/s10508-011-9777-6

Cohen-Kettenis, P. T., Schagen, S. E. E., Steensma, T. D., de Vries, A. L. C., & Delemarre-van de Waal, H. A. (2011). Puberty Suppression in a Gender-Dysphoric Adolescent: A 22-Year Follow-Up. Archives of Sexual Behavior, 40(4), 843–847. https://doi.org/10.1007/s10508-011-9758-9